The molecular mechanisms that guide the rejection of the pork organs in the xenotrapriants have been studied with an unprecedented detail.
A careful observation of the reception reserved by the human immune system to a pork kidney has produced a considerable step forward in the knowledge of rejection mechanismsthe main obstacle to the practice of xenotrapriants.
The xenotrapriants are transplants of organs, tissues or cells from animals to humans and are often indicated as a possible solution to the lack of transplant organs. On the compatibility of the organs (pork, and genetically modified to be better tolerated by man) with the body of the recipients, however, there is still a long way to go.
Live interactions
A group of scientists from the Transplant Institute and the regeneration of organs in Paris and the Institute for Transplantation of New York University Lanone has studied with cutting -edge techniques of molecular imaging The interactions between human immune cells and the tissue of a pork kidneyto grasp the first signs of rejection “live”. Human immune cells seemed to be widespread in every part of the pork kidney filtering system.
In particular, i macrophages (the “brush” white blood cells, which incorporate and neutralize pathogens) and the myeloid cells (bone marrow cells that give rise to white blood cells, red blood cells and platelets) seem to be the main mediatory cells of the reactions of rejection.
These they started around the tenth day But they reached a peak at the 33rd: they begin soon and develop progressively, as suggested by previous observations. An important information to identify the window of time in which to intervene with anti -relevant therapies.
Intervene before it’s too late
In fact, when scientists introduced therapies targeted on the immune cells presentand since the first molecular signs of rejection, these signals have weakened. This progress, together with the best knowledge on Where They interact the organs of the organ and the human ones, it will help to refine therapies to improve the tolerance of the human body to the organs from xenotrapriants.
The study arrives while the wait for the results of the first clinical experimentation on the xenotraprists of kidneys of pigs, which will be carried out in the United States initially out of 6 people and then, if the results are encouraging, out of 44.
